Siskiyou Pass is a historic mountain pass in the Siskiyou Mountains of Jackson County in the U.S. state of Oregon. It is the most used pass in Oregon. The Hudson's Bay Company (HBC) made the Siskiyou Trail over the pass before pioneers traversed it with their wagons, while still later it evolved into a stage road, a railroad line, and a highway route. The name Siskiyou is believed to be derived from Cree, meaning "bob-tailed horse". Siskiyou Pass is west of the summit of Interstate 5, which is known as Siskiyou Summit.